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David J Chambers Selected Research

Induced Heart Arrest (Cardioplegia)

1/2022Normothermic blood polarizing versus depolarizing cardioplegia in a porcine model of cardiopulmonary bypass.
12/2019St Thomas' Hospital polarizing blood cardioplegia improves hemodynamic recovery in a porcine model of cardiopulmonary bypass.
1/2019Left ventricular dysfunction after two hours of polarizing or depolarizing cardioplegic arrest in a porcine model.
1/2018Efficacy of esmolol cardioplegia during hypothermic ischaemia.
7/2017Myocardial energy metabolism and ultrastructure with polarizing and depolarizing cardioplegia in a porcine model.
7/2016Myocardial function after polarizing versus depolarizing cardiac arrest with blood cardioplegia in a porcine model of cardiopulmonary bypass.
1/2013Future perspective of cardioplegic protection in cardiac surgery.
9/2012Ischaemic postconditioning: does cardioplegia influence protection?
7/2010Cardioplegia and cardiac surgery: pharmacological arrest and cardioprotection during global ischemia and reperfusion.
4/2009Targeting for cardioplegia: arresting agents and their safety.
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David J Chambers Research Topics

Disease

7Heart Arrest (Cardiac Arrest)
01/2022 - 02/2003
6Ischemia
12/2019 - 08/2002
2Stroke (Strokes)
01/2019 - 07/2016
2Hypothermia
01/2018 - 06/2017
1Thrombocytopenia (Thrombopenia)
01/2019
1Lung Injury
11/2014
1Lung Diseases (Lung Disease)
11/2014
1Infarction (Infarctions)
09/2012
1Sepsis (Septicemia)
06/2009
1Movement Disorders (Movement Disorder)
01/2009
1Nocturia
01/2009
1Sleep Initiation and Maintenance Disorders (Insomnia)
01/2009
1Orthostatic Hypotension (Postural Hypotension)
01/2009
1Reperfusion Injury
01/2005
1Hyperkalemia
08/2002

Drug/Important Bio-Agent (IBA)

3esmolol (Brevibloc)FDA LinkGeneric
01/2018 - 08/2002
2SolutionsIBA
01/2018 - 08/2002
2St. Thomas' Hospital cardioplegic solutionIBA
07/2017 - 09/2012
2MagnesiumIBA
07/2017 - 09/2012
2Oxygen (Dioxygen)IBA
06/2017 - 08/2002
2PotassiumIBA
01/2013 - 12/2005
1MicroRNAs (MicroRNA)IBA
12/2019
1Heparin (Liquaemin)FDA LinkGeneric
01/2019
1Cardioplegic SolutionsIBA
07/2017
1Adenosine (Adenocard)FDA LinkGeneric
07/2017
1Phosphates (Orthophosphate)IBA
07/2017
1p38 Mitogen-Activated Protein KinasesIBA
11/2014
1Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
11/2014
1Theophylline (Theon)FDA LinkGeneric
11/2014
1Mitogen-Activated Protein Kinase 3IBA
11/2014
1Mitogen-Activated Protein KinasesIBA
11/2014
1AntibodiesIBA
06/2009
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2009
1Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA
01/2009
1Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA
01/2009
1Serotonin and Noradrenaline Reuptake InhibitorsIBA
01/2009
1Norepinephrine (Noradrenaline)FDA LinkGeneric
01/2009
1Antidepressive Agents (Antidepressants)IBA
01/2009
1Serotonin (5 Hydroxytryptamine)IBA
01/2009
1Glyburide (Glibenclamide)FDA LinkGeneric
12/2005
1chelerythrineIBA
12/2005
1Protein Kinase CIBA
12/2005
1Adenosine Triphosphate (ATP)IBA
12/2005
1mitochondrial K(ATP) channelIBA
12/2005
1P-SelectinIBA
01/2005
1Creatine Kinase (Creatine Phosphokinase)IBA
04/2004
1ChloridesIBA
04/2004
1CalciumIBA
02/2003
1Krebs-Henseleit solutionIBA
08/2002
1NitrogenIBA
08/2002
1Carbon DioxideIBA
08/2002

Therapy/Procedure

11Induced Heart Arrest (Cardioplegia)
01/2022 - 08/2002
7Cardiopulmonary Bypass (Heart-Lung Bypass)
01/2022 - 01/2005
1Heart Transplantation (Grafting, Heart)
06/2017